Speed Post News Network
New Delhi : Scientists from the Institute of Nano Science and Technology (INST), Mohali, Punjab, an autonomous institute under the Department of Science & Technology, have developed a starch-based ‘hemostat’ material that concentrates the natural clotting factors in blood by physically absorbing excess fluid. The biodegradable microparticles that combine to form a gel on a wound offer significant improvements over existing alternatives. After a serious injury, few challenges are more urgent than stopping life-threatening bleeding.
The early-stage development of the material has been published in the journal Materialia, and Dr Deepa Ghosh and her colleagues who worked on it hope to develop a versatile, potentially life-saving, and inexpensive product that would be a more realistic solution for lower-income economies worldwide. The product has increased absorption capacity, improved absorption, inexpensive, biocompatible as well as biodegradable, according to a PIB release.
Hemostat materials absorb excel fluid by concentrating the natural clotting factors in the blood that are critical for stopping the blood flow; however, the bleeding can restart when non-biodegradable materials are removed.
By chemically modifying natural starch to form microparticles, Dr.Ghosh’s team has combined the advantages of biocompatibility and biodegradability with a five- to ten-fold increase in fluid absorption and much-improved adhesion. When the microparticles combine, they create an adherent gel that can remain on the wound until slowly dissipating as healing proceeds.
Dr. Ghosh said that the few starch-based biodegradable options currently available are limited by their relatively slow fluid absorption and poor adhesion to wounded tissues. Besides, being rigid, imperfect biocompatibility are problems encountered in currently available options. “Presently, no single hemostatic agent exists that can work in all situations,” said Dr. Ghosh. She added that current hemostat materials are very expensive and available mostly in developed countries.
Dr. Ghosh added, “These encouraging results suggest our modified starch microparticles are a very promising candidate for further exploration in clinical applications.”