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Patna : Top seed Daniil Medvedev, 25, Russia; 2nd seed Stefanos Tsitsipas, 22, Greece; 3rd seed Alexander Zverev, 24, Germany; and World No 26 John Isner, 36, USA, reached Round of 16 Western & Southern Open, an ATP Masters 1,000 points event, at Cincinati, Ohio, USA, on August 18, 2021, late night.

World No 2 Medvedev brushed aside World No 64 Mackenzie McDonald, 26, USA,  in straight sets 6-2, 6-2 in just 59 minutes in 2nd round firing 10 Aces. The top seed won 5 break points in the match to 1 by McDonald. Medvedev committed 3 double faults in the match to to 1 by the American. The Russian won 5 games in a row during the match to 2 by the American. Medvedev, in all, won 59 points during the match to 37 by McDonald. Medvedev will face World Nio 21 Grigor Dimitrov, 30, Bulgaria, in Round of 16 on August 19, 2021, night.

World No 3 Tsitsipas defeated World N0 45 Sebastian Korda, 21, USA, in straight sets 7-6, 6-3 in 2nd round in 1 hr 39 minutes . Both the players fired 7 Aces each during the match. Tsitsipas though committed 4 double faults during the match to 1 by Korda. But, the Greek also won 2 break points during the match besides winning the tiebreak. Tsitsipas also won 4 games in a row during the match.Tsitsipas will face World No 27 Lorenzo Sonego, 26, Italy, in Round of 16.

World No 5 Zverev beat World No 46 Lloyd Harris, 24, South Africa, 7-6, 6-2 in 2nd round in 76 minutes. Both the players hammered 11 Aces each during the match. harris committed 3 double faults to 1 by Zverev. The German won 2 break points in the match besides winning the tiebreak. Zverev also won 5 games in a row during the match. Zverev will face World No 93 Guido Pella, 31, Argentina, kin Round of 16 on August 19, 2021, late night.

World No 26 Isner upset 11th Jannik Sinner, 20, Italy, in a tough three-set contest 5-7, 7-6, 6-4 in 2nd round rallying back from one set down. Isner hammered 12 Aces during the match to 10 by Sinner. Bothe the players won 1 break point each during the match. Isner won the  tiebreak. Both the players won 3 games in a row during the match. The American, in all, won 103  points during the match to 106 points by Sinner. Isner will face World No 50 Benoit Paire, 32, France, in Round of 16 on August 19, 2021, night.